Chronic Myeloproliferative Neoplasms: Some Remaining Challenges
نویسندگان
چکیده
منابع مشابه
Philadelphia-negative chronic myeloproliferative neoplasms
Chronic myeloproliferative diseases without the Philadelphia chromosome marker (Ph-), although first described 60 years ago, only became the subject of interest after the turn of the millennium. In 2001, the World Health Organization (WHO) defined the classification of this group of diseases and in 2008 they were renamed myeloproliferative neoplasms based on morphological, cytogenetic and molec...
متن کاملChronic Myeloproliferative Neoplasms: a Collaborative Approach
The classic chronic myeloproliferative neoplasms (MPN) include different entities that pose significant challenges for their optimal diagnosis, treatment and overall management. Polycythemia Vera and Essential Thrombocythemia are the most common among chronic myeloproliferative neoplasms (MPNs); major causes of morbidity and mortality are represented by arterial and venous thrombosis, as well a...
متن کاملEpigenetics and mutations in chronic myeloproliferative neoplasms.
The BCR-ABL1-negative classic myeloproliferative neoplasms, polycythemia vera (PV), essential thrombocytemia (ET) and primary myelofibrosis are clonal stem cell disorders associated with an increased production of mature blood cells belonging preferentially to one cell linage. They share substantial phenotypic mimicry, can undergo phenotypic shifts (from PV to ET and vice versa) as well as evol...
متن کاملMyeloproliferative neoplasms and thrombosis.
Major causes of morbidity and mortality in myeloproliferative neoplasms are represented by arterial and venous complications, progression to myelofibrosis, and transformation to acute leukemia. The pathogenesis of thrombosis results from a complex interplay of clinical and disease-related factors. Abnormalities of blood cells arising from the clonal proliferation of hematopoietic stem cells inv...
متن کاملMyelodysplastic/myeloproliferative neoplasms.
According to the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, myelodysplastic/myeloproliferative neoplasms are clonal myeloid neoplasms that have some clinical, laboratory, or morphologic findings that support a diagnosis of myelodysplastic syndrome, and other findings that are more consistent with myeloproliferative neoplasms. These disorders ...
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ژورنال
عنوان ژورنال: HemaSphere
سال: 2018
ISSN: 2572-9241
DOI: 10.1097/hs9.0000000000000147